反应详情

To a solution of (E)-3-(4-fluoro-2-methylphenyl)acrylic acid (13 g, 72.22 mmol) in EtOH (250 mL) was added PtO2 (250 mg) and then hydrogenated at 30 psi for 3 h. The reaction mixture was filtered on a Celite® pad, washed with MeOH (100 mL), and the filtrate was concentrated, washed with diethyl ether (20 mL), n-pentane (50 mL) and dried in vacuo to give 3-(4-fluoro-2-methylphenyl)propanoic acid as an off-white solid (10 g, 77%).

1. filtrationThe reaction mixture was filtered on a Celite® pad
2. washwashed with MeOH (100 mL)
3. concentrationthe filtrate was concentrated
4. washwashed with diethyl ether (20 mL), n-pentane (50 mL)
5. customdried in vacuo