反应详情

温度

75 °C

Ethyl 2-(5-bromo-3-(2,4-dimethoxybenzylamino)pyrazin-2-ylamino)acetate (0.484 g, 1.138 mmol), methanol (0.461 mL, 11.38 mmol) and TFA (7 mL) were combined in a sealable vessel with a stirbar. The system was purged with nitrogen. The resulting mixture was sealed, stirred vigorously and heated at 75° C. in an oil bath for 25 min. The resulting mixture was diluted with water (14 mL) and stirred at room temperature for 5 min. Solids were collected by vacuum filtration, washed with water and diethyl ether and dried under high vacuum to give the desired product (0.375 g, 1.093 mmol, 96% yield) as a pink solid. MS (ESI) m/z 229.0 [M]+, 231.3 [M+2]+.

1. customThe system was purged with nitrogen
2. customThe resulting mixture was sealed
3. additionThe resulting mixture was diluted with water (14 mL)
4. stirringstirred at room temperature for 5 min
5. filtrationSolids were collected by vacuum filtration
6. washwashed with water and diethyl ether
7. customdried under high vacuum