反应详情

温度

80 °C

To a solution of 4-bromo-2-fluoro-5-methylbenzonitrile (40 g, 190 mmol) in a mixture of sulfuric acid (98%) and TFA (v/v=4:1, 480 mL) was stirred at 80° C. for 16 h. After the mixture was cooled to room temperature, the resulting mixture was poured into ice-cold water. The resulting precipitate was collected by filtration, washed with water and dried under reduced pressure to give the title compound (41 g, 95% yield) as a white solid. MS (ESI) m/z 232.0 [M+1]+.

1. temperatureAfter the mixture was cooled to room temperature
2. additionthe resulting mixture was poured into ice-cold water
3. filtrationThe resulting precipitate was collected by filtration
4. washwashed with water
5. customdried under reduced pressure