Phosphorus oxychloride → HCID 45123408, compound

HRID 717222Notes

Reaction equation

HRID 717222 reaction equation
[CH3:1][C:2]1([C:5](O)=O)[CH2:4][CH2:3]1.[NH2:8][NH:9][C:10]([NH2:12])=[S:11].P(Cl)(Cl)(Cl)=O>>[CH3:1][C:2]1([C:5]2[S:11][C:10]([NH2:12])=[N:9][N:8]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 813261-Methylcyclopropanecarboxylic acidHCID 2723789Thiosemicarbazide

Product 1

HCID 45123408HCID 45123408, compound

Procedure

Commercially available, 1-methyl-cyclopropane-1-carboxylic acid (Aldrich), thiosemicarbazide (Aldrich) and phosphorus oxychloride (Aldrich) were processed as described for Example 1A to obtain the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.84-0.93 (m, 2H), 0.93-1.03 (m, 2H), 1.41 (s, 3H), 6.94 (s, 2H); MS (ESI+) m/z 156 (M+H)+.

Sources & evidence

ORD record
ord-64ab85caff4f4b2386ced7df318f23c5
Source dataset
uspto-grants-2015_11
Patent number
US09193713B2

Reaction notes

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