Phosphorus oxychloride → HCID 71650980, compound

HRID 717223Notes

Reaction equation

[CH3:1][C:2]([CH3:8])([C:6]#[CH:7])[C:3](O)=O.[NH2:9][NH:10][C:11]([NH2:13])=[S:12].P(Cl)(Cl)(Cl)=O>>[CH3:1][C:2]([C:3]1[S:12][C:11]([NH2:13])=[N:10][N:9]=1)([CH3:8])[C:6]#[CH:7]

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 2723789Thiosemicarbazide

HCID 139056472,2-Dimethylbut-3-ynoic acid

Product 1

HCID 71650980HCID 71650980, compound

Procedure

Commercially available, 2,2-dimethylbut-3-ynoic acid (Betapharma), thiosemicarbazide (Aldrich) and phosphorus oxychloride (Aldrich) were processed as described for Example 1A to obtain the title compound. MS (ESI+) m/z 168 (M+H)+.

Sources & evidence

ORD record: ord-faf26a36b2ad498aad52f2195ef53059
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09193713B2

Reaction notes

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