Hydrochloric Acid → 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

HRID 717265Notes

Reaction equation

HRID 717265 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680841Methyl 5-methyl-2-(pyridin-4-yl)benzoate

Product 1

HCID 866808425-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of methyl 5-methyl-2-(pyridin-4-yl)benzoate (8.8 g), 6 N hydrochloric acid (65 mL) and acetic acid (100 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained solid was washed with ethyl acetate to give the title compound (6.6 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-ec3c87a7dfc84ef99350a30a7c5ee439
Source dataset
uspto-grants-2015_11
Patent number
US09193709B2

Reaction notes

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