Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride

HRID 717278Notes

Reaction equation

HRID 717278 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680852Methyl 2-(pyrimidin-4-yl)benzoate

Product 1

HCID 866808532-(Pyrimidin-4-yl)benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-69a1efb8df094e82b03cddcfe50f5647
Source dataset
uspto-grants-2015_11
Patent number
US09193709B2

Reaction notes

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