2-Fluorophenylboronic acid → HCID 71284101, compound

HRID 717533Notes

Reaction equation

HRID 717533 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[N:14][CH:13]=3)[CH2:9][C:8](=[O:18])[NH:7][C:6]=2[CH:19]=1.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O>>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[N:14][CH:13]=3)[CH2:9][C:8](=[O:18])[NH:7][C:6]=2[CH:19]=1

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 71284108HCID 71284108, compound

Product 1

HCID 71284101HCID 71284101, compound

Procedure

The title compound was prepared from 8-bromo-4-(pyridazin-4-yl)-1H-benzo[b][1,4]diazepin-2(3H)-one (Example 1; 1 mmol) and commercial available 2-fluorophenylboronic acid (CAS-No: 1993-03-9; 1.5 mmol) according to the general procedure G. Obtained as a yellow solid (67%), MS (EI) 333 [(M+1)+].

Sources & evidence

ORD record
ord-10a41ee52c234ca6984407ecb6622d43
Source dataset
uspto-grants-2015_11
Patent number
US09193710B2

Reaction notes

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