反应详情

温度

0 °C

3,4-Dihydro-1H-quinoxalin-2-one (500 mg, 3.378 mmol) was dissolved in 3N HCl (10 mL) and stirred for 5 min. at 0° C. A solution of sodium nitrite (256 mg, 3.716 mmol) in water (2 mL) was added at 0° C., and the reaction mixture was stirred for 2 h at RT. After completion of reaction, water was added and the mixture extracted twice with DCM (100 mL). The combined organic layers were washed with water, dried over sodium sulfate and concentrated under reduced pressure to obtain 400 mg of 3,4-dihydro-4-nitrosoquinoxalin-2(1H)-one.

1. stirringthe reaction mixture was stirred for 2 h at RT
2. additionwas added
3. extractionthe mixture extracted twice with DCM (100 mL)
4. washThe combined organic layers were washed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure