2,3-Dihydro-1,4-benzothiazine → 4-nitroso-3,4-dihydro-2H-benzo[b][1,4]thiazine

Participants

Reaction Conditions

Reaction Steps

3,4-Dihydro-2H-benzo[1,4]thiazine (1.2 g, 7.94 mmol) was dissolved in 3N HCl at 0° C., and the reaction mixture stirred for 5 min. at 0° C. A solution of sodium nitrite (548 mg, 7.94 mmol) in water was added at the same temperature, and the reaction mixture stirred at 0° C. for 1 h. After completion of reaction water was added and extracted with DCM. The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure, to provide 1 g desired product.

Provenance & Evidence