反应详情

温度

0 °C

3,4-Dihydro-2H-benzo[1,4]thiazine (1.2 g, 7.94 mmol) was dissolved in 3N HCl at 0° C., and the reaction mixture stirred for 5 min. at 0° C. A solution of sodium nitrite (548 mg, 7.94 mmol) in water was added at the same temperature, and the reaction mixture stirred at 0° C. for 1 h. After completion of reaction water was added and extracted with DCM. The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure, to provide 1 g desired product.

1. stirringthe reaction mixture stirred at 0° C. for 1 h
2. additionwas added
3. extractionextracted with DCM
4. dry with materialThe combined organic layers were dried over sodium sulfate
5. concentrationconcentrated under reduced pressure