Hydrochloric Acid → HCID 86691932, compound

Participants

Reaction Conditions

Reaction Steps

7-Methyl-2-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (1.4 g) was dissolved in ethanol (6.5 mL), and to it was added 1N HCl (6.5 mL). The reaction mixture was cooled to 0° C., and a solution of sodium nitrite (0.858 g) in water (23 mL) was added. After addition, the reaction mixture was stirred for 2 h at RT. The reaction was monitored by TLC. After completion of reaction, the mixture was evaporated and dried under high vacuum (1.5 g). The crude compound was carried forward to the next step without further purification.

Provenance & Evidence