Hydrochloric Acid → HCID 86691932, compound

HRID 717786Notes

Reaction equation

HRID 717786 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]=2[CH:17]=1.Cl.[N:19]([O-])=[O:20].[Na+]>C(O)C.O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([N:19]=[O:20])[CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]=2[CH:17]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 67379097HCID 67379097, compound

Product 1

HCID 86691932HCID 86691932, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

7-Methyl-2-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (1.4 g) was dissolved in ethanol (6.5 mL), and to it was added 1N HCl (6.5 mL). The reaction mixture was cooled to 0° C., and a solution of sodium nitrite (0.858 g) in water (23 mL) was added. After addition, the reaction mixture was stirred for 2 h at RT. The reaction was monitored by TLC. After completion of reaction, the mixture was evaporated and dried under high vacuum (1.5 g). The crude compound was carried forward to the next step without further purification.

Workup

  1. additionAfter addition
  2. customAfter completion of reaction
  3. customthe mixture was evaporated
  4. customdried under high vacuum (1.5 g)
  5. customThe crude compound was carried forward to the next step without further purification

Sources & evidence

ORD record
ord-0607a13eab4c4b9697c3431daccf20ef
Source dataset
uspto-grants-2015_11
Patent number
US09193728B2

Reaction notes

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