Hydrochloric Acid → HCID 86701944, compound

HRID 717931Notes

Reaction equation

HRID 717931 reaction equation
CC(C)(S([NH:6][C:7]1([C:11]2[S:15][C:14]([C:16]([NH:18][CH2:19][C:20]3[CH:25]=[CH:24][N:23]4[CH:26]=[CH:27][N:28]=[C:22]4[CH:21]=3)=[O:17])=[CH:13][CH:12]=2)[CH2:10][O:9][CH2:8]1)=O)C.Cl.O1CCOCC1>CO>[NH2:6][C:7]1([C:11]2[S:15][C:14]([C:16]([NH:18][CH2:19][C:20]3[CH:25]=[CH:24][N:23]4[CH:26]=[CH:27][N:28]=[C:22]4[CH:21]=3)=[O:17])=[CH:13][CH:12]=2)[CH2:10][O:9][CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86701945HCID 86701945, compound

Product 1

HCID 86701944HCID 86701944, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(3-(1,1-Dimethylethylsulfinamido)oxetan-3-yl)-N-(imidazo[1,2-a]pyridin-7-ylmethyl)thiophene-2-carboxamide (432 mg, 1 mmol) in 10 ml methanol was treated with 4N aqueous HCl in dioxane (0.75 ml, 3 mmol) and the mixture was stirred for 2 hours. Concentration provided the title compound.

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-8e339baae364448dbe8103bac36857ea
Source dataset
uspto-grants-2015_11
Patent number
US09193723B2

Reaction notes

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