4-Bromophenyl isocyanate → 1-(4-Bromophenyl)-3-(imidazo[1,2-a]pyridin-7-ylmethyl)urea

HRID 717944Notes

Reaction equation

HRID 717944 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][C:5]=12.[Br:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[O:21])=[CH:15][CH:14]=1>ClCCl>[Br:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:11][CH2:10][C:7]2[CH:8]=[CH:9][N:4]3[CH:3]=[CH:2][N:1]=[C:5]3[CH:6]=2)=[O:21])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 756094-Bromophenyl isocyanateHCID 55289825Imidazo(1,2-a)pyridin-7-ylmethanamine

Product 1

HCID 867019581-(4-Bromophenyl)-3-(imidazo[1,2-a]pyridin-7-ylmethyl)urea

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of imidazo[1,2-a]pyridin-7-ylmethanamine (500 mg, 3.40 mmol) in dichloromethane (17 ml) at room temperature was added 1-bromo-4-isocyanatobenzene (680 mg, 3.40 mmol) as a single portion. The resulting suspension was stirred overnight and then filtered with dichloromethane washes to give the title compound.

Workup

  1. filtrationfiltered with dichloromethane

Sources & evidence

ORD record
ord-d8c197d8d1c94c2fb037089a33115bd0
Source dataset
uspto-grants-2015_11
Patent number
US09193723B2

Reaction notes

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