HCID 34176367, compound → 3-Phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

HRID 718116Notes

Reaction equation

HRID 718116 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:9][N:10]=2)[CH:5]=[CH:6][N:7]=1.[H][H]>CCO.[Pd]>[C:11]1([C:8]2[N:4]3[CH2:5][CH2:6][NH:7][CH2:2][C:3]3=[N:10][N:9]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 2

HCID 34176367HCID 34176367, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 341763603-Phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazineYield 100.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Title compound 472 (310 mg, 1.34 mmol) was dissolved in EtOH (25 mL) and 10% Pd/C (75 mg, 25% w/w) was added. The reaction mixture was stirred under 1 atmosphere of hydrogen over night. The catalyst was filtered and the filtrate was evaporated to afford title compound 473 (269 mg, 100%). MS (m/z): 201.1 (M+H).

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-c69ed56040004f348914d5c0e1fd9ee3
Source dataset
uspto-grants-2015_11
Patent number
US09193749B2

Reaction notes

Loading…