Hydrochloric Acid → HCID 59783511, compound

HRID 718126Notes

Reaction equation

HRID 718126 reaction equation
Cl.C([O:6][C:7]([C@@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[N:19]=[CH:18][C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][N:15]=1)=[O:8])(C)(C)C>O1CCOCC1>[CH2:23]([O:22][C:20]([C:17]1[CH:16]=[N:15][C:14]([N:10]2[CH2:11][CH2:12][CH2:13][C@H:9]2[C:7]([OH:8])=[O:6])=[N:19][CH:18]=1)=[O:21])[CH3:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59783510HCID 59783510, compound

Product 1

HCID 59783511HCID 59783511, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

HCl in dioxane (3 mL) was added to compound 498 (278 mg, 0.865 mmol) and the reaction mixture was stirred overnight. The reaction was then concentrated to afford compound 499 which was used without further purification. MS (m/z): 266.2 (M+H).

Workup

  1. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-2f5449dee58e4bd5ac4f2e01e306d109
Source dataset
uspto-grants-2015_11
Patent number
US09193749B2

Reaction notes

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