反应详情

Acetamidine hydrochloride (1.05 g, 11.1 mmol) and dimethyl 2-(4-fluorobenzamido)malonate (1.0 g, 3.71 mmol) were added to a solution of sodium (0.26 g, 11.1 mmol) in ethanol (37 ml). The reaction mixture was refluxed for 3 hours. Then, after cooling, the solid product was collected and washed with ethanol. The product was dissolved in a minimal volume of water and acidified to pH 4-5 with 5M HCl. The precipitate was collected, washed with water and dried to give the title compound as a white solid (0.77 g, 79%).

1. temperatureThe reaction mixture was refluxed for 3 hours
2. temperatureThen, after cooling
3. customthe solid product was collected
4. washwashed with ethanol
5. dissolutionThe product was dissolved in a minimal volume of water
6. customThe precipitate was collected
7. washwashed with water
8. customdried