反应详情

A suspension of tert-butyl 4-(2-(4-chlorophenoxy)acetyl)piperazine-1-carboxylate (example 58, 0.58 g, 0.16 mmol) in dichloromethane (8 ml) was treated dropwise at room temperature with TFA until the solid completely dissolved. The reaction mixture was stirred under nitrogen at room temperature overnight. The volatiles were evaporated to dryness, diluted with water and the solid was collected by filtration. The solid was washed with water and dried to yield the title compound as a white solid (0.30 g, 72%).

1. dissolutioncompletely dissolved
2. customThe volatiles were evaporated to dryness
3. additiondiluted with water
4. filtrationthe solid was collected by filtration
5. washThe solid was washed with water
6. customdried