反应详情

Formamidine acetate (0.46 g, 4.46 mmol) and dimethyl 2-(4-fluorobenzamido)malonate (1.0 g, 3.71 mmol) were added to a solution of sodium (0.17 g, 7.43 mmol) in ethanol (37 ml). The reaction mixture was refluxed for 3 hours. After cooling down, the precipitate was filtered off and washed with ethanol. The product was dissolved in a minimal volume of water and acidified to pH 4-5 with 5M HCl. The precipitate was collected, washed with water and dried to yield the title compound as a white solid (0.60 g, 64%).

1. temperatureThe reaction mixture was refluxed for 3 hours
2. temperatureAfter cooling down
3. filtrationthe precipitate was filtered off
4. washwashed with ethanol
5. dissolutionThe product was dissolved in a minimal volume of water
6. customThe precipitate was collected
7. washwashed with water
8. customdried