反应详情

A Dean-Stark condenser was attached, and a mixture of compound (51) (52.4 g, 213.8 mmol) prepared in Example 1, EG (39.8 g, 641.4 mmol) and PTSA (0.52 g, 1 wt %) was refluxed in a toluene (300 mL) solvent for 3 hours. The reaction mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate, water and saturated brine, and dried over magnesium sulfate. Toluene was distilled off by an evaporator, and thus 2-(6-bromo-2-fluoro-3-propylphenyl)-1,3-dioxolane (78) (61.2 g, yield 99.0%) was obtained.

1. washThe reaction mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate, water and saturated brine
2. dry with materialdried over magnesium sulfate
3. distillationToluene was distilled off by an evaporator