Trifluoroacetic acid methylene chloride → HCID 131734173, compound

HRID 718630Notes

Reaction equation

HRID 718630 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([C:13]([CH:28]4[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]4)=[C:14]([C:16]#[C:17][C:18]4[CH:27]=[CH:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)[N:15]=3)[N:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.[C:41]([OH:47])([C:43]([F:46])([F:45])[F:44])=[O:42].C(Cl)Cl>>[OH:47][C:41]([C:43]([F:46])([F:45])[F:44])=[O:42].[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([C:13]([CH:28]4[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]4)=[C:14]([C:16]#[C:17][C:18]4[CH:27]=[CH:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)[N:15]=3)[N:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 117732499HCID 117732499, compound

Product 1

HCID 131734173HCID 131734173, compound

Procedure

A solution of compound 41e (0.50 g, 0.93 mol) in TFA/DCM (1:3, 10 mL) was stirred at rt for 2 h. The resulting mixture was concentrated under reduced pressure to obtain compound 41f as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C26H26N6O: 439.2 (M+H). found: 439.2.

Workup

  1. concentrationThe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e68f2e602cd7410baca82eba0ca072ef
Source dataset
uspto-grants-2015_11
Patent number
US09193736B2

Reaction notes

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