Sodium Carbonate → HCID 178513260, compound

Participants

Role	Name	HCID	Charge
Reactant	Sodium Carbonate	HCID 10340	—
Reactant	Hydroxyamine hydrochloride	HCID 443297	—
Reactant	5-(8-Morpholino-2-(2-(quinolin-2-yl)ethynyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile	HCID 117728357	—
Solvent	Ethanol	HCID 702	—
Product	HCID 178513260	HCID 178513260	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

A mixture of compound 39a (0.20 g, 0.44 mmol), hydroxylamine hydrochloride (0.20 g, 2.9 mmol) and sodium carbonate (0.20 g, 1.9 mmol,) in ethanol (4 mL) was stirred at 80° C. for 1 h. The reaction mixture was cooled to rt, and the solids formed were collected by filtration and washed with Et2O (2×30 mL) to obtain compound 42a as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C27H22N8O2: 491.2 (M+H). Found: 491.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09193736B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-9ae20c63f5c24d79a381724969cd131e
Source note	uspto-grants-2015_11