反应详情

温度

80 °C

To a solution of 4-bromobenzaldehyde (4.3 g, 23 mmol) and 1-amino-1-methylurea (2.5 g, 28 mmol) in EtOH (40 mL) was added AcOH (2.5 mL) and water (4.5 mL). The resulting solution was stirred overnight at 80° C. and allowed to cool to rt. A precipitate formed by the addition of Et2O (50 mL). The solids were collected by filtration and compound 51a was obtained as a white solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C9H10BrN3O: 256.0 (M+H). Found 256.1.

1. temperatureto cool to rt
2. filtrationThe solids were collected by filtration