2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline → 1-Methyl-3-[4-[8-(morpholin-4-yl)-2-[2-(quinolin-2-yl)ethyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]-4-[[2-(trimethylsilyl)ethoxy]methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one

Participants

Role	Name	HCID	Charge
Reactant	2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline	HCID 117728694	—
Reactant	1-Methyl-3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-[[2-(trimethylsilyl)ethoxy]methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one	HCID 131734177	—
Product	1-Methyl-3-[4-[8-(morpholin-4-yl)-2-[2-(quinolin-2-yl)ethyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]-4-[[2-(trimethylsilyl)ethoxy]methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one	HCID 123938244	—

Reaction Steps

Compound 46a was subjected to Suzuki coupling conditions with compound 51d as described in Example 38, Step A to obtain compound 51e as a light yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C36H42N8O3Si: 663.3 (M+H). Found: 663.4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09193736B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-9304abbbab7c4374aa96150b1ff41b35
Source note	uspto-grants-2015_11