HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline → 1-(4-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)-4-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline | HCID 117728694 | — |
| Reactant | 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5(4H)-one | HCID 131734179 | — |
| Product | 1-(4-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)-4-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5(4H)-one | HCID 123932123 | — |
Reaction Steps
Compound 46a (0.30 g, 0.68 mmol) was subjected to Suzuki coupling conditions with compound 53c using the procedures described in Example 38, Step A to obtain compound 53d as a white solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C34H39N9O3Si: 650.3 (M+H). Found: 650.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-a43f893c8cfa4ad98b4bbbb623f257c2 |
| Source note | uspto-grants-2015_11 |