3-Bromoanisole → 3-(3-Methoxyphenyl)-8-morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde

HRID 718700Notes

Reaction equation

HRID 718700 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([CH:13]=[C:14]([CH:16]=[O:17])[N:15]=3)[N:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.Br[C:19]1[CH:20]=[C:21]([O:25][CH3:26])[CH:22]=[CH:23][CH:24]=1>>[CH3:26][O:25][C:21]1[CH:20]=[C:19]([C:13]2[N:9]3[N:10]=[CH:11][CH:12]=[C:7]([N:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)[C:8]3=[N:15][C:14]=2[CH:16]=[O:17])[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 169713-BromoanisoleHCID 1177286388-Morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde

Product 1

HCID 1177283103-(3-Methoxyphenyl)-8-morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde

Procedure

Compound 5e (162 mg, 0.698 mmol) was coupled with 3-bromoanisole (0.13 mL, 1.04 mmol) according to the procedures described in Example 20, Step A to obtain compound 77a. Mass spectrum (LCMS, ESI pos.) Calcd. For C18H18N4O3 339.1 (M+H). found 339.2.

Sources & evidence

ORD record
ord-89a8a04edfb54799b7bec3c0ff7598d9
Source dataset
uspto-grants-2015_11
Patent number
US09193736B2

Reaction notes

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