Trifluoroacetic acid → 4-(6-Chloro-8-morpholino-2-((1R,2S)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzoic acid trifluoroacetic acid salt

Participants

Reaction Steps

Compound 81a (30 mg, 0.05 mmol) was treated with TFA using the procedures previously described in Example 80 to afford the title compound 165. 1H NMR (400 MHz, CD3OD) δ (ppm): 8.87 (d, J=8.6 Hz, 1H), 8.20 (d, J=8.6 Hz, 1H), 8.02-8.12 (m, 2H), 7.99 (t, J=8.1 Hz, 1H), 7.84 (t, J=7.1 Hz, 1H), 7.71 (d, J=9.1 Hz, 1H), 7.58-7.66 (m, 2H), 6.46 (s, 1H), 4.05-4.14 (m, 4H), 3.85-3.95 (m, 4H), 3.18-3.25 (m, 1H), 3.08-3.16 (m, 1H), 2.22-2.30 (m, 1H), 2.16 (m, 1H); Mass Spectrum (LCMS, ESI pos.): Calcd. for C29H24ClN5O3: 526.1 (M+H). found: 526.3.

Provenance & Evidence