反应详情

Compound 81a (30 mg, 0.05 mmol) was treated with TFA using the procedures previously described in Example 80 to afford the title compound 165. 1H NMR (400 MHz, CD3OD) δ (ppm): 8.87 (d, J=8.6 Hz, 1H), 8.20 (d, J=8.6 Hz, 1H), 8.02-8.12 (m, 2H), 7.99 (t, J=8.1 Hz, 1H), 7.84 (t, J=7.1 Hz, 1H), 7.71 (d, J=9.1 Hz, 1H), 7.58-7.66 (m, 2H), 6.46 (s, 1H), 4.05-4.14 (m, 4H), 3.85-3.95 (m, 4H), 3.18-3.25 (m, 1H), 3.08-3.16 (m, 1H), 2.22-2.30 (m, 1H), 2.16 (m, 1H); Mass Spectrum (LCMS, ESI pos.): Calcd. for C29H24ClN5O3: 526.1 (M+H). found: 526.3.