反应详情

To a solution of 23 (0.012 g, 0.022 mmol) in DMSO (2 mL) were added 7 (0.011 g, 0.0289 mmol) and triethylamine (0.01 mL, 0.071 mmol) under an atmosphere of argon, and the mixture was stirred at room temperature. After 16 h, the crude mixture was directly purified by preparative HPLC to afford 25 (0.005 g, 42%), 24 (0.0014 g, 8.2%) and unreacted 7 (0.0037 g, 48%). 1H NMR (400 MHz, DMSO) δ 8.39 (s, 2H), 7.86 (s, 1H), 7.49-7.37 (m, 1H), 7.04-6.82 (m, 2H), 6.53 (s, 2H), 3.59-3.36 (m, 11H), 3.03-2.93 (m, 2H), 2.84-2.76 (m, 2H), 2.33-2.16 (m, 5H), 2.05-1.96 (m, 2H), 1.44-1.31 (m, 3H), 1.25-1.16 (m, 3H). MS (ESI) m/z calcd for C26H38N5O8 [M+H]+ 548.6, found 548.5.

1. customthe crude mixture was directly purified by preparative HPLC