反应详情

Activated palladium on carbon (10% w/w, 26 mg) was added to a solution of the azide 7 (258 mg, 1.10 mmol) in MeOH (40 mL). The reaction flask was purged thrice with H2 (g), pressurized to 4 bar with H2 (g), and mechanically shaken in a Parr hydrogenator for 3.5 hours. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure to yield amine 8 as a yellow oil that was used immediately in the next step without further purification.

1. customThe reaction flask was purged thrice with H2 (g)
2. filtrationThe reaction mixture was filtered
3. concentrationThe filtrate was concentrated under reduced pressure