6-(Azidomethyl)phenanthridine → Phenanthridin-6-ylmethanamine

Participants

Reaction Steps

Activated palladium on carbon (10% w/w, 26 mg) was added to a solution of the azide 7 (258 mg, 1.10 mmol) in MeOH (40 mL). The reaction flask was purged thrice with H2 (g), pressurized to 4 bar with H2 (g), and mechanically shaken in a Parr hydrogenator for 3.5 hours. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure to yield amine 8 as a yellow oil that was used immediately in the next step without further purification.

Provenance & Evidence