HRID71884

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID536683

Oxazolidine

C3H7NO

结构：COC(=O)NC(C(=O)NC(CO)c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5C(=O)C(NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C

HCID66620379

未命名化合物

HCID66621051

未命名化合物

PRODUCTS

生成物

结构：COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CC6(CC6)CN5C(=O)C(NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C

HCID66621024

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

was prepared in a similar fashion to (1-{2-[5-(4′-{2-[2-Hydroxy-1-(2-methoxycarbonylamino-3-methyl-butyrylamino)-ethyl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester, replacing the oxazolidine derived carboxylic acid with the corresponding 4-cyclopropyl-proline derivative and using HCl in dioxane for the Boc deprotection.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-40489271826541b6b8c271af9c74db81
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822430B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH3:1][O:2][C:3](=[O:53])[NH:4][CH:5]([C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]1[NH:17][C:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]4[NH:34][C:35]([CH:38]([NH:41][C:42](=[O:52])[CH:43]([NH:47][C:48]([O:50][CH3:51])=[O:49])[CH:44]([CH3:46])[CH3:45])[CH2:39]O)=[N:36][CH:37]=4)=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)=[CH:19][N:20]=1)=[O:10])[CH:6]([CH3:8])[CH3:7].O1CCNC1.[CH:59]1([CH:62]2CN[C@H](C(O)=O)C2)[CH2:61][CH2:60]1.Cl>O1CCOCC1>[CH3:51][O:50][C:48](=[O:49])[NH:47][CH:43]([C:42]([N:41]1[CH:38]([C:35]2[NH:34][C:33]([C:30]3[CH:29]=[CH:28][C:27]([C:24]4[CH:23]=[CH:22][C:21]([C:18]5[NH:17][C:16]([CH:12]6[CH2:13][CH2:14][CH2:15][N:11]6[C:9](=[O:10])[CH:5]([NH:4][C:3]([O:2][CH3:1])=[O:53])[CH:6]([CH3:8])[CH3:7])=[N:20][CH:19]=5)=[CH:26][CH:25]=4)=[CH:32][CH:31]=3)=[CH:37][N:36]=2)[CH2:39][C:59]2([CH2:61][CH2:60]2)[CH2:62]1)=[O:52])[CH:44]([CH3:46])[CH3:45]