Methylhydrazine → Ethyl 2-(1-methylhydrazinyl)acetate

HRID 718879Notes

Reaction equation

[CH3:1][NH:2][NH2:3].Br[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]>>[CH3:1][N:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])[NH2:3]

Participants

Reactant 2

HCID 6061Methylhydrazine

HCID 7748Ethyl bromoacetate

Product 1

HCID 20288078Ethyl 2-(1-methylhydrazinyl)acetateYield 77.2%

Procedure

According to the procedure described in the synthesis method of Compound XV-1 with the modification that the reaction was carried out overnight, methylhydrazine 7.13 ml (150 mmol) was reacted with ethyl 2-bromoacetate 16.7 g (100 mmol) to obtain the title compound 10.2 g (77%).

Workup

customdescribed in the synthesis method of Compound XV-1 with the modification that the reaction

Sources & evidence

ORD record: ord-37bbbc975dcb4789991e119d43875f6e
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09193734B2

Reaction notes

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