Lithium hydroxide, monohydrate → 2-(1-Methyl-2-((thiophen-2-ylmethyl)carbamoyl)hydrazinyl)acetic acid

HRID 718888Notes

Reaction equation

HRID 718888 reaction equation
[CH3:1][N:2]([CH2:13][C:14]([O:16]CC)=[O:15])[NH:3][C:4](=[O:12])[NH:5][CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1.O.[OH-].[Li+]>>[CH3:1][N:2]([CH2:13][C:14]([OH:16])=[O:15])[NH:3][C:4](=[O:12])[NH:5][CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67088516Ethyl 2-(1-methyl-2-(thiophen-2-ylmethylcarbamoyl)hydrazinyl)acetate

Product 1

HCID 533975262-(1-Methyl-2-((thiophen-2-ylmethyl)carbamoyl)hydrazinyl)acetic acidYield 82%

Procedure

According to the procedure described in the synthesis method of Compound VI-2 with the modification that the reaction was carried out for 2 hours, ethyl 2-(1-methyl-2-(thiophen-2-ylmethylcarbamoyl)hydrazinyl)acetate (Compound V-13) 1.38 g (5.1 mmol) was reacted with lithium hydroxide monohydrate 426 mg (10.1 mmol) to obtain the title compound 1.0 g (82%).

Workup

  1. customdescribed in the synthesis method of Compound VI-2 with the modification that the reaction

Sources & evidence

ORD record
ord-07e9952533c94354aba41d12bc9bb63a
Source dataset
uspto-grants-2015_11
Patent number
US09193734B2

Reaction notes

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