HRID718916

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

结构：CCOC(OCC)[C@H](C)N(Cc1cccc2nsnc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21

HCID86698532

未命名化合物

PRODUCTS

生成物

结构：CCOC(OCC)[C@H](C)N(Cc1cccc2nsnc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1

HCID67075006

未命名化合物

收率 139.7%

PROCEDURE

实验过程

According to the procedure described in the synthesis method of Compound IV-1, (9H-fluoren-9-yl)methyl (S)-1-((benzo[c][1,2,5]thiadiazol-4-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-3-(4-tert-butoxyphenyl)-1-oxopropan-2-ylcarbamate (Compound III-4) 509 mg (0.69 mmol) was treated with piperidine and purified on silica gel column chromatography (n-hexane:ethyl acetate=9:1, chloroform:methanol=100:0 and 8:2) to obtain the title compound 496 mg (139%).

WORKUP

后处理

custompurified on silica gel column chromatography (n-hexane:ethyl acetate=9:1, chloroform:methanol=100:0 and 8:2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0909c38b56324cfeb728718e20ace62a
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09193734B2
来源说明: uspto-grants-2015_11

反应 SMILES

[N:1]1[S:2][N:3]=[C:4]2[C:9]([CH2:10][N:11]([C@@H:45]([CH3:53])[CH:46]([O:50][CH2:51][CH3:52])[O:47][CH2:48][CH3:49])[C:12](=[O:44])[C@@H:13]([NH:26]C(=O)OCC3C4C=CC=CC=4C4C3=CC=CC=4)[CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:17][CH:16]=3)=[CH:8][CH:7]=[CH:6][C:5]=12.N1CCCCC1>>[NH2:26][C@@H:13]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:17][CH:16]=1)[C:12]([N:11]([CH2:10][C:9]1[C:4]2[C:5](=[N:1][S:2][N:3]=2)[CH:6]=[CH:7][CH:8]=1)[C@@H:45]([CH3:53])[CH:46]([O:50][CH2:51][CH3:52])[O:47][CH2:48][CH3:49])=[O:44]