HCID 21896882, compound → HCID 178467022, compound

HRID 719129Notes

Reaction equation

HRID 719129 reaction equation
ClC1C=CC(C(N)C(N)CC(C)C)=CC=1.Cl.C(OC1C=C(OC)C=CC=1C(=N)OCC)C.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]2[NH:44][C:43]([C:45]3[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][C:46]=3[O:53][CH2:54][CH3:55])=[N:42][CH:41]2[CH2:56][CH:57]2[CH2:61]CC[CH2:58]2)=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:35]=[CH:36][C:37]([CH:40]2[NH:44][C:43]([C:45]3[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][C:46]=3[O:53][CH2:54][CH3:55])=[N:42][CH:41]2[CH2:56][CH:57]([CH3:58])[CH3:61])=[CH:38][CH:39]=1

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 21896899HCID 21896899, compoundHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178467022HCID 178467022, compound

Procedure

5-(4-Chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4-isobutyl-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-4-methyl-pentane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 387.1837, calculated for C22H28N2O2Cl [(M+H)+]387.1834.

Sources & evidence

ORD record
ord-b64601ee56e94635ac5f4560fb35dacd
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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