HCID 21896882, compound → HCID 178440011, compound

HRID 719136Notes

Reaction equation

HRID 719136 reaction equation
ClC1C=CC(C(N)C(N)CCC)=CC=1.Cl.C(OC1C=C(OC)C=CC=1C(=N)OCC)C.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([CH:39]2[NH:43][C:42]([C:44]3[CH:49]=[CH:48][C:47]([O:50][CH3:51])=[CH:46][C:45]=3[O:52][CH2:53][CH3:54])=[N:41][CH:40]2[CH2:55][CH:56]2CCC[CH2:57]2)=[CH:35][CH:34]=1>>[Cl:32][C:33]1[CH:34]=[CH:35][C:36]([CH:39]2[NH:43][C:42]([C:44]3[CH:49]=[CH:48][C:47]([O:50][CH3:51])=[CH:46][C:45]=3[O:52][CH2:53][CH3:54])=[N:41][CH:40]2[CH2:55][CH2:56][CH3:57])=[CH:37][CH:38]=1

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 218968861-(4-Chloro-phenyl)-pentane-1,2-diamineHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178440011HCID 178440011, compound

Procedure

5-(4-Chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4-propyl-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-pentane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 373.1680, calculated for C21H26N2O2Cl [(M+H)+]373.1678.

Sources & evidence

ORD record
ord-31ebf4501c824ded83c39e6927473d63
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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