Hydrochloric Acid → HCID 59610343, compound

HRID 71914Notes

Reaction equation

HRID 71914 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[C:17]3[C:12](=[CH:13][C:14]([Br:18])=[CH:15][CH:16]=3)[O:11][CH2:10][C:9]=2[CH:19]=1)=[O:4].[OH-].[Na+].Cl>C1COCC1.CO>[Br:18][C:14]1[CH:13]=[C:12]2[C:17]([C:8]3[CH:7]=[CH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:19][C:9]=3[CH2:10][O:11]2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59611418HCID 59611418, compound

Product 1

HCID 59610343HCID 59610343, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Conditions

Temperature
25 °C

Procedure

The solution of 3-Bromo-6H-benzo[c]chromene-8-carboxylic acid methyl ester (160 mg, 0.5 mmol) and sodium hydroxide (1.0 N, 1 ml, 1 mmol) in THF/MeOH (2 ml/2 ml) was heated at 50° C. for 3 hours. The mixture was cooled to 25° C. and was acidified with 2 N HCl (0.6 ml). The solvents were removed under reduced pressure. The mixture was diluted with acetonitrile and water, and was freezer-dried to give 3-Bromo-6H-benzo[c]chromene-8-carboxylic acid as brown powder.

Workup

  1. customThe solvents were removed under reduced pressure
  2. additionThe mixture was diluted with acetonitrile and water
  3. customwas freezer-dried

Sources & evidence

ORD record
ord-6c4b29f449204b57ac5d624abd6715b0
Source dataset
uspto-grants-2014_09
Patent number
US08822430B2

Reaction notes

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