[5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone → HCID 11490110, compound

HRID 719150Notes

Reaction equation

HRID 719150 reaction equation
FC(F)(F)C(O)=O.ClC1C=CC([CH:15]2N[C:18]([C:20]3C=CC(OC)=[CH:22][C:21]=3OCC)=[N:17][CH:16]2[CH:31]2CCCC2)=CC=1.[Cl:36][C:37]1[CH:42]=[CH:41][C:40]([CH:43]2[N:47]([C:48]([N:50]3[CH2:55]CN(C)C[CH2:51]3)=[O:49])[C:46]([C:57]3[CH:62]=[CH:61][C:60]([O:63][CH3:64])=[CH:59][C:58]=3[O:65][CH2:66][CH3:67])=[N:45][CH:44]2[CH2:68][CH:69]2[CH2:73][CH2:72][CH2:71]C2)=[CH:39][CH:38]=1>>[Cl:36][C:37]1[CH:38]=[CH:39][C:40]([CH:43]2[N:47]([C:48]([N:50]3[CH2:55][CH2:31][CH:16]([N:17]4[CH2:22][CH2:21][CH2:20][CH2:18]4)[CH2:15][CH2:51]3)=[O:49])[C:46]([C:57]3[CH:62]=[CH:61][C:60]([O:63][CH3:64])=[CH:59][C:58]=3[O:65][CH2:66][CH3:67])=[N:45][CH:44]2[CH:68]2[CH2:69][CH2:73][CH2:72][CH2:71]2)=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 11193096[5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanoneHCID 178467014HCID 178467014, compound

Product 1

HCID 11490110HCID 11490110, compound

Procedure

[5-(4-Chloro-phenyl)-4-cyclopentyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone was prepared from 5-(4-chloro-phenyl)-4-cyclopentyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole, trifluoroacetate salt (Example 19) in an analogous manner as described for the preparation of [5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone (Example 24). HR-MS (ES, m/z) observed 579.3104, calculated for C33H44N4O3Cl [(M+H)+]579.3097.

Sources & evidence

ORD record
ord-0c5d7845e11e4ce7a87f43bb7fac2e6d
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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