反应详情

温度

80 °C

To a solution of 5-bromotetralone (see Reference Example 1C)(5.0 g) in N,N-dimethylformamide (20 mL) was added copper (1) cyanide (6.39 g) and the reaction mixture heated to reflux for 20 hours. The reaction mixture was then cooled to 80° C. and a solution of FeCl3.6H2O (24 g) in water (38 mL) was added. After stirring for a further 45 minutes the reaction mixture was cooled, diluted with water, extracted into toluene, washed with water, dried (MgSO4) and the solvent removed in vacuo to yield 5-cyano-1-tetralone as a yellow solid.

1. temperaturethe reaction mixture heated
2. temperatureto reflux for 20 hours
3. temperaturewas cooled
4. extractionextracted into toluene
5. washwashed with water
6. dry with materialdried (MgSO4)
7. customthe solvent removed in vacuo