Dimethylamine → HCID 178483814, compound

HRID 719197Notes

Reaction equation

HRID 719197 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:21]2[C:12](=[N:13][C:14]3[C:19]([N:20]=2)=[C:18]2[CH:22]=[CH:23][C:24]([OH:26])=[CH:25][C:17]2=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1)=[O:7].[CH3:28][NH:29][CH3:30].[CH2:31]=O>C(O)(=O)C.O>[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:21]2[C:12](=[N:13][C:14]3[C:19]([N:20]=2)=[C:18]2[CH:22]=[CH:23][C:24]([OH:26])=[C:25]([CH2:28][N:29]([CH3:31])[CH3:30])[C:17]2=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1)=[O:7]

Participants

6

Reactant 3

HCID 674DimethylamineHCID 712FormaldehydeHCID 178483816HCID 178483816, compound

Product 1

HCID 178483814HCID 178483814, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

3-Hydroxy-benzo[a]phenazine-11-carboxylic acid (2-dimethylamino-ethyl)-amide (26 mg) was sonicated in acetic acid (2 mL) to give a fine suspension. To this was added a 40% solution of dimethylamine in water (3 mL) and a 37% solution of formaldehyde in water (3 mL). The reaction mixture was left stirring for 2 days. The volatiles were then removed in vacuo to yield the title compound (29 mg).

Workup

  1. customto give a fine suspension
  2. waitThe reaction mixture was left
  3. customThe volatiles were then removed in vacuo

Sources & evidence

ORD record
ord-022a8e4f364444a4af77b7c076646fcb
Source dataset
uspto-grants-2006_11
Patent number
US07132419B2

Reaction notes

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