Pyridine-2-carbonyl chloride → N-[5-(3,4-Dimethoxyphenyl)-3-methyl-1H-pyrazol-4-yl]pyridine-2-carboxamide

HRID 719269Notes

Reaction equation

HRID 719269 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:15][N:14]=[C:13]([CH3:16])[C:12]=2[NH2:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24](Cl)=[O:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:15][N:14]=[C:13]([CH3:16])[C:12]=2[NH:17][C:24]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=2)=[O:25])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 135034Pyridine-2-carbonyl chlorideHCID 178489090HCID 178489090, compound

Product 1

HCID 178489093N-[5-(3,4-Dimethoxyphenyl)-3-methyl-1H-pyrazol-4-yl]pyridine-2-carboxamide

Procedure

The preparation took place in analogy with Example 15a), starting with 200 mg of 5-(3,4-dimethoxyphenyl)-3-methyl-1H-pyrazol-4-ylamine (44) and 168 mg of pyridine-2-carbonyl chloride*HCl. The following was obtained: 55 C18H18N4O3 (338.37); MS (ESI) 339 (M+H)

Workup

  1. customThe following was obtained

Sources & evidence

ORD record
ord-ccab9572a1c44b8597b9bbba7e441b2b
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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