HCID 178434573, compound → HCID 178434202, compound

HRID 719280Notes

Reaction equation

HRID 719280 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:18])=[N:9][NH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O>O>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11]2[NH:10][N:9]=[C:8]([CH3:18])[C:7]=2[N:6]=1

Participants

3

Reactant 1

HCID 178434573HCID 178434573, compound

Product 1

HCID 178434202HCID 178434202, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The preparation took place in analogy to Example 33 (B), using 401 mg of 2-chloro-N-(3-methyl-5-phenyl-1H-pyrazol-4-yl)-benzamide. The reaction mixture was diluted with water and extracted with dichloromethane. The organic portion was concentrated under reduced pressure and purified by MPLC (4 g SiO2, dichloromethane/methanol=99/1→50/50) to give the title compound.

Workup

  1. extractionextracted with dichloromethane
  2. concentrationThe organic portion was concentrated under reduced pressure
  3. custompurified by MPLC (4 g SiO2, dichloromethane/methanol=99/1→50/50)

Sources & evidence

ORD record
ord-3662fb9a5fab49abba2cd0e52db6b782
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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