HCID 178425843, compound → HCID 178423932, compound

HRID 719281Notes

Reaction equation

HRID 719281 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([NH:8][C:9]2[C:10]([CH3:20])=[N:11][NH:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=O)=[CH:4][CH:3]=1>O>[CH3:20][C:10]1[C:9]2[N:8]=[C:6]([C:5]3[CH:21]=[CH:22][C:2]([CH3:1])=[CH:3][CH:4]=3)[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13]=2[NH:12][N:11]=1

Participants

3

Reactant 1

HCID 178425843HCID 178425843, compound

Product 1

HCID 178423932HCID 178423932, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The preparation took place in analogy to example 33 (B), using 192 mg of 4-methyl-N-(3-methyl-5-phenyl-1H-pyrazol-4-yl)-benzamide, except the reaction mixture was diluted with water and extracted with dichloromethane. The organic portion was concentrated under reduced pressure and purified by MPLC (4 g SiO2, dichloromethane/methanol, gradient=99/1→50/50) to give the title compound.

Workup

  1. extractionextracted with dichloromethane
  2. concentrationThe organic portion was concentrated under reduced pressure
  3. custompurified by MPLC (4 g SiO2, dichloromethane/methanol, gradient=99/1→50/50)

Sources & evidence

ORD record
ord-5a3542caebc84fc292bac5e252375eba
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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