Phosphorus oxychloride → HCID 178434203, compound

HRID 719282Notes

Reaction equation

HRID 719282 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:18])=[N:9][NH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.P(Cl)(Cl)(Cl)=O>C(OCC)(=O)C.ClCCl>[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11]2[NH:10][N:9]=[C:8]([CH3:18])[C:7]=2[N:6]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178434574HCID 178434574, compound

Product 1

HCID 178434203HCID 178434203, compound

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

The preparation took place in analogy to example 34 (D) using 182 mg of 2-fluoro-N-(3-methyl-5-phenyl-1H-pyrazol-4-yl)-benzamide, except 10.7 ml of phosphorous oxychloride was used and the reaction was stirred for 4 hrs. Trituration of the residue with ethyl acetate/dichloromethane (1/1) gave the title compound as a cream solid.

Sources & evidence

ORD record
ord-9a44b26b98e64684b2b833a1b9e26ca5
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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