Tin tetrachloride → HCID 178434205, compound

HRID 719283Notes

Reaction equation

HRID 719283 reaction equation
[F:1][C:2]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:18])=[N:9][NH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.Cl[Sn](Cl)(Cl)Cl>O>[F:1][C:2]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:3]=1[C:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11]2[NH:10][N:9]=[C:8]([CH3:18])[C:7]=2[N:6]=1

Participants

4

Reactant 2

HCID 24287Tin tetrachlorideHCID 178434576HCID 178434576, compound

Product 1

HCID 178434205HCID 178434205, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The preparation took place in analogy to example 33 (B) using 233 mg of 2,4-difluoro-N-(3-methyl-5-phenyl-1H-pyrazol-4-yl)-benzamide, except the reaction mixture was heated for 4 h after addition of SnCl4, and addition of water gave a tan precipitate. This material was triturated with hot methanol to give a solid that was further triturated with dichloromethane and methanol to give the title compound as a white solid.

Workup

  1. temperatureexcept the reaction mixture was heated for 4 h
  2. customgave a tan precipitate
  3. customThis material was triturated with hot methanol
  4. customto give a solid
  5. customthat was further triturated with dichloromethane and methanol

Sources & evidence

ORD record
ord-cd0a690d543c47d2b482311bcc3bffc9
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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