2,4,6-Trichlorobenzenesulfonyl chloride → HCID 10275773, compound

HRID 719313Notes

Reaction equation

HRID 719313 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([NH2:13])[S:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[F:14].[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[C:17]=1[S:24](Cl)(=[O:26])=[O:25]>>[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[C:17]=1[S:24]([NH:13][C:11]1[S:10][CH:9]=[C:8]([C:6]2[CH:5]=[CH:4][C:3]([F:14])=[C:2]([CH3:1])[CH:7]=2)[N:12]=1)(=[O:26])=[O:25]

Participants

3

Reactant 2

HCID 5213352,4,6-Trichlorobenzenesulfonyl chlorideHCID 27564332-amino-4-(4-fluoro-3-methylphenyl)-1,3-thiazole

Product 1

HCID 10275773HCID 10275773, compound

Procedure

The title compound was prepared from 2-amino-4-(4′-fluoro-3′-methyl)phenylthiazole and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (50.9 mg) with purity >90%: MS (pos) m/z 451.0, 453.0, 455.0; HRMS m/z 449.9218 (calc. of monoisotopic mass for C16H10Cl3FN2O2S2 gives 449.9233).

Sources & evidence

ORD record
ord-4f2f18478908401584320ba2a2eeb3ad
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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