N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamide → N-[4-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide

HRID 719319Notes

Reaction equation

HRID 719319 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=2)[N:6]=1.[CH2:17]([C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1)[CH2:18][CH3:19]>>[CH2:17]([C:20]1[CH:25]=[CH:24][C:23]([S:26]([NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7]3[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:11][CH:12]=3)[N:6]=2)(=[O:28])=[O:27])=[CH:22][CH:21]=1)[CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 519881N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamideHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 8504637N-[4-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide

Procedure

The title compound was prepared from N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (1.0 mg) with purity >80%. MS (pos) m/z 416.2.

Sources & evidence

ORD record
ord-6e1cd245a7844984bb3d46c1f4e9c52b
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

Loading…