3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-(7-methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)-2-methylbenzenesulfonamide

HRID 719326Notes

Reaction equation

HRID 719326 reaction equation
Br.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[C:10]1[N:11]=[C:12]([NH2:14])[S:13][C:9]=1[CH2:8][CH2:7]2.[Cl:18][C:19]1[C:20]([CH3:29])=[C:21]([S:25](Cl)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1>>[Cl:18][C:19]1[C:20]([CH3:29])=[C:21]([S:25]([NH:14][C:12]2[S:13][C:9]3[CH2:8][CH2:7][C:6]4[C:15](=[CH:16][CH:17]=[C:4]([O:3][CH3:2])[CH:5]=4)[C:10]=3[N:11]=2)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 28074737-Methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-amine hydrobromide

Product 1

HCID 102956873-Chloro-N-(7-methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)-2-methylbenzenesulfonamide

Procedure

The title compound was prepared from 7-methoxy-4,5-dihydronaphto[1,2-D][1,3]thiazol-2-amine hydrobromide and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (30.7 mg) with purity >90%. MS (pos) m/z 421.1.

Sources & evidence

ORD record
ord-2d9575272ad5423ab484eb46751c350f
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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